Original scientific paper

https://doi.org/10.2478/acph-2013-0029

Quantification of ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets by NIR-chemometry

IOAN TOMUŢĂ ; Iuliu HaţieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023, Cluj-Napoca, Romania
DANA DUDAŞ ; Iuliu HaţieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023, Cluj-Napoca, Romania
ANDREEA LOREDANA VONICA ; S.C. Polipharma Industries, 550052, Sibiu, Romania
SORIN E. LEUCUŢA ; Iuliu HaţieganuUniversity of Medicine and Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, 400023, Cluj-Napoca, Romania

Abstract

The paper proposes a near infrared methodable to directlyand simultaneously quantify ascorbic acid and sodium ascorbate in powder blends for tableting and in vitamin C chewable tablets without any sample preparation.In the first step, calibration models for the quantification of ascorbic acid and sodium ascorbate in powder blends for tabletingand subsequently in chewable vitamin C tablets (corresponding to 80–120 % active substance) were developed according to an experimental design with 2 variables and 5 levels. Then, using the best calibration models, the methods were fully validatedin terms of recovery, precision and accuracyfor both powder blends and vitamin Cchewable tablets.The validated concentration range was 15.14–18.51 % for ascorbic acid and 12.06–14.49 % for sodium ascorbate in powder blends and 91.85–111.03 mg per tablet for ascorbic acid and 71.01–84.50 mg per tablet for sodium ascorbate in tablets. Validation results showed good precision and accuracy.

Keywords

NIR spectroscopy; chemometrics; ascorbic acid; sodium ascorbate; validation; powder blends

Hrčak ID:

103921

URI

https://hrcak.srce.hr/103921

Publication date:

30.9.2013.

Visits: 4.160 *