Original scientific paper
https://doi.org/10.2478/10004-1254-64-2013-2290
Percutaneous Toxicity and Decontamination of Soman, VX, and Paraoxon in Rats Using Detergents
Jan Misík
; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Růžena Pavliková
; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Jiří Cabal
; Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
Kamil Kuča
; Faculty of Military Health Sciences, University of Defence1, University Hospital2, Hradec Kralove, Czech Republic
Abstract
Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents - soman (GD) and VX. Four commercial detergents were tested as decontaminants – NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM. Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with ArgosTM (PR=2.3 to 64.8), followed by DermogelTM (PR=2.4 to 46.1). NeodekontTM and FloraFreeTM provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2).
Keywords
ArgosTM; chemical warfare agent; DermogelTM; FloraFreeTM; mass decontamination; military toxicology; NeodekontTM; protective ratio
Hrčak ID:
103927
URI
Publication date:
18.6.2013.
Visits: 2.101 *