Original scientific paper
https://doi.org/10.2478/10004-1254-64-2013-2248
Melatonin Improves Liver Function in Benzene-treated Rats
Seema Sharma
; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
Suresh Vir Singh Rana
; Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University Meerut, Meerut, India
Abstract
In this study, we investigated the beneficial effects of melatonin against benzene-induced liver function impairments in Wistar rats. After 30 days of treatment, it significantly lowered hepatosomatic indices, bilirubin, and hydroxyproline in male and female benzene-treated rats. Even though it did not influence aspartate aminotransferase, melatonin had beneficial effects on alanine aminotransferase and alkaline phosphatase. Our results suggest that melatonin is an effective modulator of liver function in benzenetreated rats thanks to its antioxidative properties.
Keywords
alkaline phosphatase; antioxidants; bilirubin; hydroxyproline; serum transaminases
Hrčak ID:
103928
URI
Publication date:
18.6.2013.
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