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Professional paper

Cryptococcus neoformans Meningoencephalitis in a Patient with Idiopathic CD4+ T Lymphocytopenia

Ivica Pavić ; University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia
Đurđica Cekinović ; University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia
Josip Begovac ; University of Zagreb, »Dr. Fran Mihaljevi}« University Hospital for Infectious Diseases, Zagreb, Croatia
Tomislav Maretić ; University of Zagreb, »Dr. Fran Mihaljevi}« University Hospital for Infectious Diseases, Zagreb, Croatia
Rok Čivljak ; University of Zagreb, »Dr. Fran Mihaljevi}« University Hospital for Infectious Diseases, Zagreb, Croatia
Biserka Trošelj-Vukić ; University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia


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Abstract

Cryptococcus neoformans is a leading cause of invasive cryptoccocal infections which include meningitis/meningoencephalitis, cerebral cryptococcoma, invasive pulmonary and mediastinal infection. Invasive infection is mainly diagnosed in immunocompromised patients, especially in HIV-infected individuals. There is a rising number of patients with invasive cryptococcal infections in immunocompromised patients who are HIV-negative. Among several primary immunodeficiency syndromes, considered as possible reasons for these invasive infections, idiopathic CD4+ T lymphocytopenia (ICL) is most frequently diagnosed. The pathogenesis of this rare syndrome is still unknown, while its clinical
spectrum ranges from an asymptomatic laboratory abnormality to life-threatening opportunistic infections. Here we present an HIV-negative young man suffering from cryptococcal meningoencephalitis in whom ICL was diagnosed.

Keywords

Cryptococcal meningoencephalitis, CD4+ T cell immunodeficiency, HIV

Hrčak ID:

104752

URI

https://hrcak.srce.hr/104752

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