Professional paper
Cryptococcus neoformans Meningoencephalitis in a Patient with Idiopathic CD4+ T Lymphocytopenia
Ivica Pavić
; University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia
Đurđica Cekinović
; University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia
Josip Begovac
; University of Zagreb, »Dr. Fran Mihaljevi}« University Hospital for Infectious Diseases, Zagreb, Croatia
Tomislav Maretić
; University of Zagreb, »Dr. Fran Mihaljevi}« University Hospital for Infectious Diseases, Zagreb, Croatia
Rok Čivljak
; University of Zagreb, »Dr. Fran Mihaljevi}« University Hospital for Infectious Diseases, Zagreb, Croatia
Biserka Trošelj-Vukić
; University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia
Abstract
Cryptococcus neoformans is a leading cause of invasive cryptoccocal infections which include meningitis/meningoencephalitis, cerebral cryptococcoma, invasive pulmonary and mediastinal infection. Invasive infection is mainly diagnosed in immunocompromised patients, especially in HIV-infected individuals. There is a rising number of patients with invasive cryptococcal infections in immunocompromised patients who are HIV-negative. Among several primary immunodeficiency syndromes, considered as possible reasons for these invasive infections, idiopathic CD4+ T lymphocytopenia (ICL) is most frequently diagnosed. The pathogenesis of this rare syndrome is still unknown, while its clinical
spectrum ranges from an asymptomatic laboratory abnormality to life-threatening opportunistic infections. Here we present an HIV-negative young man suffering from cryptococcal meningoencephalitis in whom ICL was diagnosed.
Keywords
Cryptococcal meningoencephalitis; CD4+ T cell immunodeficiency; HIV
Hrčak ID:
104752
URI
Publication date:
1.7.2013.
Visits: 1.296 *