Veterinary Archives, Vol. 69 No. 1, 1999.
Original scientific paper
Reduction of dichlorvos-induced toxicosis in rabbits by levamisole.
Imad Ibrahim Aldabagh
; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Iraq
Fouad Kasim Mohammad
; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Iraq
Abstract
The toxicity and interaction of levamisole with dichlorvos were examined in male rabbits. Signs of levamisole (25, 50 and 75 mg/kg, subcutaneously) poisoning in rabbits were dose-dependent, and the highest dose produced excessive salivation, lacrimation, ataxia and tremors in all the rabbits. This dose induced convulsion and death in 50 and 75% of the rabbits, respectively. Levamisole at 25 and 75% did not significantly affect erythrocyte acetylcholinesterase (EChE) activity at 2 and 24 h after treatment. Dichlorvos dosing at 10 and 20 mg/kg, orally dose-dependently induced signs of cholinergic toxicity. The 20 mg/kg dose of dichlorvos caused death in 75% of the rabbits. Levamisole pretreatment at 50 mg/kg protected the rabbits against dichlorvos (20 mg/kg, orally) induced toxicosis, prevented the occurrence of convulsion, gasping and death, and significantly increased the latency to onset of tremor in comparison with the dichlorvos-treated control group. Combined levamisole (50 mg/kg) and dichlorvos (10 mg/kg) treatments caused a significantly higher degree of EChE inhibition at 2 and 24 h post-treatment in comparison with the dichlorvos-treated group. The data suggest that levamisole protects rabbits intoxicated with dichlorvos, irrespective of the extent of EChE inhibition.
Keywords
levamisole; dichlorvos; rabbit; erythrocyte cholinesterase symptoms; organophosphate
Hrčak ID:
104936
URI
Publication date:
21.2.1999.
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