Case report
Dilated Cardiomyopathy in an Adult Human Immunodeficinecy Virus Type 1-Infected Patient Treated with an Abacavir-Containing Antiretroviral Regimen
Marta Perović Mihanović
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Šime Zekan
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Davorka Lukas
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Josip Begovac
; Klinika za infektivne bolesti "Dr. Fran Mihaljević", Zagreb, Hrvatska
Abstract
A54-year-old adult human immunodeficiency virus type 1 (HIV-1) infected patient developed cardiac failure. Echocardiographic findings were consistent with dilated cardiomyopathy (DCM); 4-chamber dilatation and a low left ventricular ejection fraction of 20% were present. The patient was given an abacavir-containing antiretroviral drug combination 31 months ago without HLA- B*5701 testing. There was no systemic hypersensitivity reaction and abacavir was not changed when it became known that he was positive for the HLA-B*5701 allele. At the time of DCM the patient had an undetectable viral load and his CD4 cell count was 669/μL. The patient was given standard treatment for heart failure and abacavir was replaced with raltegravir. In the following months his cardiac function gradually improved and after two-years his recovery was complete. Our case report suggests that abacavir could be associated with DCM in patients with well controlled HIV-infection.
Keywords
HIV infection; dilated cardiomyopathy; antiretroviral treatment; abacavir
Hrčak ID:
105204
URI
Publication date:
30.12.2012.
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