Meeting abstract
The Role of Bone Morphogenetic Proteins in Regeneration of Bone and Cartilage
S. Vukičević
Abstract
In the last ten years a significant amount of knowledge has accumulated in the field of molecular and developmental biology. New genes responsible for the skeleton development have been discovered, and their function in the postnatal life of mammals has been defined. The most important genes responsible for the morphogenesis on all three embryonic envelopes include bone morphogenetic proteins (BMPs) and cartilage derived morphogenetic proteins (CDMPs), recently renamed into morphogens. Since
their discovery, many investigators world wide have defined the morphogen receptors, signal transduction pathways, and their role in several organs. Recently, the use of recombinant human BMPs in the regeneration of long bones and the craniofacial skeleton in patients with bone non-unions have been approved in Europe, USA, Canada and Australia. In pre clinical studies it has been demonstrated that locally applied BMP-7 initiates cementogenesis, and the regeneration
of periodontal ligament and the alveolar bone. CDMPs have a promising role in articular cartilage regeneration and are also good candidates for clinical trials in humans.
Keywords
Hrčak ID:
10049
URI
Publication date:
15.9.2002.
Visits: 1.311 *