Original scientific paper

Morphometric study of the spinal cord in foetuses of diabetic pregnancies.

Hooman Hematian ; Department of Veterinary Sciences, Yasooj Branch, Islamic Azad University, Yasooj, Iran
Zabihollah Khaksar ; Department of Basic Sciences, School of Veterinary Medicine, Shiraz, University, Shiraz, Iran
Gholamali Jelodar ; Department of Basic Sciences, School of Veterinary Medicine, Shiraz, University, Shiraz, Iran

Abstract

This study was conducted to evaluate the effects of maternal diabetes on the foetal spinal cord. Sixteen adult female rats were divided into two equal groups. Diabetes was induced in one group by alloxan. Both groups became pregnant by natural mating. At days 17, 18, 19 and 20 of pregnancy, the spinal cord was collected from the foetuses of all rats, and the body mass and number of foetuses were also measured. Various histological parameters were determined using routine histological techniques. The results revealed a decrease in the transverse diameter of the spinal cord, the transverse diameter of central canal, the number of cells in the white and gray matters and an increase in the vertical diameter of the spinal cord and the vertical diameter of the central canal in the foetuses of diabetic mothers (FDM) as compared to the control group. The body mass of FDM was significantly (P<0.05) higher than that of the control and the number of foetuses in FDM was significantly (P<0.05) lower than the control. Maternal hyperglycaemia exhibited deleterious effects on the spinal cord during foetal life, which affected the shape, structure and cell number of the spinal cord.

Keywords

maternal diabetes; rat; foetus; alloxan; spinal cord

Hrčak ID:

105562

URI

https://hrcak.srce.hr/105562

Publication date:

8.7.2013.

Article data in other languages: croatian

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