Original scientific paper

https://doi.org/10.5562/cca2216

DNA Binding Properties of Two Ruthenium(III) Complexes Containing Schiff Bases Derived from Salicylaldehyde: Spectroscopic and Electrochemical Evidence of CT DNA Intercalation

Nevzeta Ljubijankić orcid.org/0000-0002-7421-4592 ; Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 35, 71000 Sarajevo, Bosnia and Herzegovina
Adnan Zahirović orcid.org/0000-0001-7662-3341 ; Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 35, 71000 Sarajevo, Bosnia and Herzegovina
Emir Turkušić ; Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 35, 71000 Sarajevo, Bosnia and Herzegovina
Emira Kahrović orcid.org/0000-0001-9067-3556 ; Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 35, 71000 Sarajevo, Bosnia and Herzegovina

Abstract

The interaction of CT DNA by two anionic Ru(III) complexes with N-substituted salicylidenimine
ligands was investigated by spectroscopic titration and cyclic voltammetry. The result gives a
surprising evidence for intercalation of DNA by the negatively charged complex species containing non
typical intercalating ligands with Kb of order 104 M−1. Na[RuCl2(N-R-5-X-salim)2], where R represents
butyl or phenyl and X = H, Cl, were characterized on the basis of elemental analysis, MALDI-TOF mass
spectrometry, infrared, UV / visible spectroscopic measurements and cyclic voltammetry. (doi:
10.5562/cca2216)

Keywords

Schiff base; ruthenium; DNA intercalation; spectroscopy; cyclic voltammetry

Hrčak ID:

105595

URI

https://hrcak.srce.hr/105595

Publication date:

1.7.2013.

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