Original scientific paper

Oxidative Stress in Patients with Scalp Seborrheic Dermatitis

Perihan Ozturk
Ozer Arican ; Trakya Unversity Medical FacultyDep of DermatologyEdirne
Ergul Belge Kurutas
Tugba Karakas
Betul Kabakci

Abstract

Seborrhoeic dermatitis (SD) is a common, chronic inflammatory skin disease that mainly affects the scalp. The objective of this study was to evaluate the activities of superoxide dismutase (SOD) and catalase (CAT) and,  levels of malondialdehyde (MDA) in scraping samples of patients with scalp SD.Thirty consecutive patientswith a diagnosis of scalp SD and thirty one healthy volunteers were enrolled. The samples were obtainedby scrapingthe skin surface of scalp. SOD and CAT activities and MDA levels were measured in scraping samples as spectrophotometric.SOD and CAT activities and MDA levels of the patients were significantly higher than in the controls (all p<0.001). There was a positive correlation between severity of the disease and itching scores (Contingency coefficient=0.671, p<0.001). Except that correlation, there was no significant correlation among ages, sexes, the duration and severity of the disease, itching scores and antioxidant enzymes and MDA levels in the patients group (p>0.05).Cutaneous oxidative stress in patients with SD may play an important role in pathogenesis of the disease. Further clinical and laboratory evaluation of oxidant/antioxidant system in patients with SD is warranted.

Keywords

Seborrhoeic dermatitis; oxidative stres; superoxide dismutase; catalase; malondialdehyde

Hrčak ID:

106670

URI

https://hrcak.srce.hr/106670

Publication date:

23.8.2013.

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