Medica Jadertina, Vol. 43 No. 3, 2013.
Professional paper
The manifestation of epidermal growth factor receptor (EGFR) in non-small-cell lung cancer
Ivan Bačić
; Zadar General Hospital, Department of Surgery, Thoracic Unit
Ana Stipčević
; Zadar General Hospital, Department of Surgery, Thoracic Unit
Neven Skitarelić
; Zadar General Hospital, Department of Otolaryngology and Maxillofacial Surgery
Abstract
Lung cancer is the most frequent malignant disease, and most often the cause of death from malignant disease in the world. Standard forms of treatment are surgery, chemotherapy and radiation treatment.
Determining the epidermal growth factor receptor (EGFR) in tumor cells enables the application of specific medication that blocks the mentioned receptor and which has a favorable therapeutic effect.
We have described, in this work, the frequency of EFGR protein expression in cells of non-small-cell lung cancer and its impact on the histological maturity of the tumor in patients that have undergone surgery at Zadar General Hospital Department of Surgery.
Conclusion: Protein EGFR expression in our material is not connecetd with tumour maturity. However, it is important to determine the EGFR status of every tumour due to adequate application of anti EGFR medications.
Keywords
lung cancer; EGFR; histological maturity of the tumor; tyrosine kinase inhibitors
Hrčak ID:
107299
URI
Publication date:
11.9.2013.
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