Acta clinica Croatica, Vol. 51. No. 4., 2012.
Original scientific paper
The Prevalence of Human Papillomavirus 16 and Epstein-Barr Virus in Patients with Oral Squamous Cell Carcinoma
Petra Nola-Fuchs
Vanja Vučićević Boras
orcid.org/0000-0003-1651-8069
Vanda Plečko
Stjepko Pleština
Aleksandar Milenović
Mato Sušić
Vlaho Brailo
Abstract
It has been suggested that certain viruses such as human papillomaviruses (HPV) and Epstein-Barr virus (EBV) might have a role in oral squamous cell carcinoma (OSCC). However, results of the published studies are controversial and are dependent on the geographic distribution and methods of sampling and sample analysis. The aim of this study was to determine the prevalence of HPV 16 and EBV in OSCC patients. In 24 patients with OSCC (mean age 59.6±8.8) and 30 controls (mean age 49.1±8.3), 5 mL of blood was collected to determine the prevalence of EBV by serologic methods. In addition, swabs were obtained to analyze the presence of HPV 16 and EBV by use of polymerase chain reaction. Statistical analysis was performed by use of Mann Whitney test, χ2-test and Spearman correlation test. The results of this study showed that there were no significant differences between OSCC patients and control subjects according to the presence of EBV or HPV 16. Therefore, it can be concluded
Keywords
Oral squamous cell carcinoma; Papillomaviruses; Epstein-Barr virus Correspondence to:
Hrčak ID:
107919
URI
Publication date:
1.12.2012.
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