Veterinary Archives, Vol. 83 No. 5, 2013.
Original scientific paper
The influence of E. coli lipopolysaccharide induced fever on the plasma kinetic of ceftriaxone in Black-Bengal goats.
Naveen Kumar
; Department of Pharmacology and Toxicology, Ranchi College of Veterinary Science and Animal Husbandry, Birsa Agriculture University, Ranchi, Jharkhand, India
Birendra K. Roy
; Department of Pharmacology and Toxicology, Ranchi College of Veterinary Science and Animal Husbandry, Birsa Agriculture University, Ranchi, Jharkhand, India
Amita Ranjan
; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Sciences, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
Abstract
The pharmacokinetic profile of ceftriaxone was studied in healthy and febrile Black Bengal goats after its single intramuscular administration at the dose rate of 50 mg/kg body mass. The fever was induced by intravenous administration of E. coli serovar O126:B8 lipopolysaccharide (1 μg/kg, IV) and the plasma drug concentration was analyzed using HPLC. The plasma drug concentration versus time curve best fi tted the two compartment open model. At 1 min the ceftriaxone concentrations in healthy and febrile animals were 40.58 ± 0.94 μg/mL and 32.83 ± 0.92 μg/mL, respectively and the drug could be detected up to 8 h in healthy goats and up to 4 h in febrile goats. The elimination half-life of ceftriaxone in febrile animals (0.95 ± 0.02 h) was lower than healthy animals (2.30 ± 0.19 h). Volume of distribution was higher in febrile animals (0.72 ± 0.01 L/kg) in comparison to healthy animals (0.15 ± 0.07 L/kg). Total body clearances in healthy and febrile animals were 5.08 ± 0.14 and 8.82 ± 0.31 mL/kg/h, respectively, suggesting extensive clearance of the drug in febrile animals. The intramuscular dose of ceftriaxone in febrile animals was calculated as 6 mg/ kg body mass, to be repeated at a 6 h interval. Results of the present study indicated that the drug distribution is altered by fever.
Keywords
ceftriaxone; dosage- regimen; fever; goat; pharmacokinetics
Hrčak ID:
108226
URI
Publication date:
27.9.2013.
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