Original scientific paper

Demineralized calf foetal growth plate effects on experimental bone healing in rabbit model.

Amin Bigham-Sadegh orcid.org/0000-0003-4981-7495 ; Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
Mohammad Shadkhast ; Department of Veterinary Anatomy and Embryology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
Mahmoud-Reza Khalegi ; Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

Abstract

The following study was designed to evaluate demineralized calf foetal growth plate (DCFGP) effects on bone healing process. A critical size defect (10 mm) was created in the radial diaphysis of 20 rabbits and then supplied with DCFGP (treatment group, n = 10) or the defect was left empty (control group, n = 10). Radiographs of each forelimb were taken postoperatively on the 1st day and at the 2nd, 4th, 6th and 8th weeks post injury to evaluate bone formation, union and remodeling of the defect. The operated radiuses were removed on the 56th postoperative day and were evaluated for histopathological criteria. This study demonstrated that DCFGP, as a xenogenic biomaterial, could promote bone regeneration in critical size defects with a high regenerative capacity, and could be an attractive alternative for reconstruction of the major diaphyseal defects of the long bones in animal models.

Keywords

demineralized callf fetal growth plate; bone healing; rabbitt

Hrčak ID:

108375

URI

https://hrcak.srce.hr/108375

Publication date:

27.9.2013.

Article data in other languages: croatian

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