Professional paper
Human protein C concentrate in a patient with meningitis and bleeding as a complication of treatment with recombinant activated protein C
MARTINA CRIVELLARI
; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
SERGIO COLOMBO
; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
MILENA MUCCI
; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
VALENTINA PLUMARI
; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
PAOLO SILVANI
; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
ALBERTO ZANGRILLO
; Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy
PATRIZIA DELLA VALLE
; Coagulation Service & Thrombosis Research Unit, San Raffaele Scientific Institute, Via Olgettina 60 Milano, 20132 Italy
ARMANDO D’ANGELO
; Coagulation Service & Thrombosis Research Unit, San Raffaele Scientific Institute, Via Olgettina 60 Milano, 20132 Italy
Abstract
Some case reports suggest that protein C zymogen supplementation may improve the outcome of patients with congenital or acquired protein C deficiency, such as sepsis-induced purpura fulminans. We describe the case report of a patient suffering from meningitis who developed a bleeding complication after recombinant human activated protein C administration and was successfully treated without any further bleeding complication with protein C concentrate. Protein C concentrate can be considered in adult patients with meningitis, even if at risk or in the presence of bleeding.
Keywords
sepsis; purpura fulminans; protein C; bleeding
Hrčak ID:
108800
URI
Publication date:
1.4.2013.
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