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Leukaemia cutis from CD56 positive, Myeloperoxidase negative acute myeloid leukaemia

Asmaa Gaber Abdou ; Dr
Iman Seleit
Ola Ahmed Bakry
Moshira Mohammed Abd elwahed

Abstract

Acute myeloid leukaemia (AML) is a clonal expansion of myeloid blasts in peripheral blood, bone marrow or other tissues. Cutaneous manifestations of leukemia are either specific or non-pecific. Specific lesions result from direct infiltration of skin by leukemic cells.  We present a case of myeloid leukemia cutis manifested by erythematous asymptomatic nodules and plaques distributed on the chest, abdomen and back. The clinical impression and the histopathological features of the cutaneous infiltrate were suggestive of haematolymphoid malignancy, more towards lymphoma.  However, the immunohistochemical features were against the diagnosis of lymphoma and were highly suspicious for myeloid leukaemia, which were concomitantly confirmed by bone marrow biopsy and blood picture.  Any poorly differentiated malignant skin infiltrate of confirmed haematopoeitic lineage, myeloid differentiation should be considered and excluded by appropriate panel.  CD56+ AML is a rare type of AML that has special features like the great liability for extramedullary involvement including skin, monocytic characteristic of leukaemia cells and absence of myeloperoxidase expression.

Keywords

leukemia cutis; acute myeloid leukemia; CD56; CD68; myeloperoxidase

Hrčak ID:

109927

URI

https://hrcak.srce.hr/109927

Publication date:

29.10.2013.

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