Veterinary Archives, Vol. 69 No. 4, 1999.
Original scientific paper
Some antidotes and paraclinical investigations in experimental intoxication with ochratoxin A and penicillic acid in chicks.
Stoytcho Stoev
; Department of Pathomorphology, Faculty of Veterinary Medicine, Trachian University, Stara Zagora, Bulgaria
Geno Anguelov
; Department of Pathophysiology, Faculty of Veterinary Medicine, Trachian University, Stara Zagora, Bulgaria
Dimitar Pavlov
; Department of Plant Science, Faculty of Zootechnics, Trachian University, Stara Zagora, Bulgaria
Ljubomir Pirovski
; Agrobiochem, Stara Zagora, Bulgaria
Abstract
The objects of this study were the main haematological and biochemical changes in experimental ochratoxicosis in 85 broiler chicks fed on a diet containing: 130, 300 and 800 ppb ochratoxin A (OTA) and 1000-2000 ppb penicillic acid (PA), corresponding to those in the field. Biochemical and haematological changes were characteristic in increased serum levels of uric acid and glucose, decreased serum levels of cholesterol and total protein, and slight normocyte anaemia. These changes were induced by several times lower contamination levels of OTA in feed than the levels described in literature of pure OTA, due to the probable synergism between OTA and PA. A positive protective effect of 5% total water extract of Artichoke and Rosallsat against the toxic effect of OTA was established.
Keywords
mycotoxic nephropathy; ochratoxicosis; ochratoxin A; penicillic acid; chicks
Hrčak ID:
110085
URI
Publication date:
22.9.1999.
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