Review article

https://doi.org/10.2478/10004-1254-64-2013-2327

Endocrine, Lifestyle, and Genetic Factors in the Development of Metabolic Syndrome

Zorana Slanovic-Kuzmanović ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ivan Kos ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ana-Marija Domijan orcid.org/0000-0001-5645-9732 ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Abstract

Metabolic syndrome (MetS) is a chronic, multi-component disease characterised by central obesity, hyperglycaemia, dyslipidaemia, and hypertension. Since MetS leads to type 2 diabetes, cardiovascular disease, development of certain cancers, and eventually to premature death, it is not surprising that it draws the attention of scientists around the world. The aetiopathology of MetS is complex and still not fully understood. This review focuses on the role of endocrine factors such as cortisol and insulin in the development of MetS. It also takes a look at some of the contributing lifestyle and genetic factors as well as at the current knowledge about its treatment.

Keywords

cardiovascular diseases; circadian rhythm; cortisol; hyperglycaemia; hypertension; insulin; MetS; type 2 diabetes

Hrčak ID:

111786

URI

https://hrcak.srce.hr/111786

Publication date:

6.12.2013.

Article data in other languages: croatian

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