Review article

Systemic thrombolysis for acute ischemic stroke treatment

Igor Antončić ; Klinika za neurologiju, KBC Rijeka, Rijeka
Siniša Dunatov ; Klinika za neurologiju, KBC Rijeka, Rijeka
Lidija Tuškan-Mohar ; Klinika za neurologiju, KBC Rijeka, Rijeka
David Bonifačić ; Klinika za neurologiju, KBC Rijeka, Rijeka
Olivio Perković ; Klinika za neurologiju, KBC Rijeka, Rijeka
Matija Sošić ; Klinika za neurologiju, KBC Rijeka, Rijeka

Abstract

In spite of the fact that ischemic stroke is an important public health problem because
of high mortality and disability, until thrombolysis was established as a standard treatment
for ischemic stroke there was no specific therapy for recanalization of occluded blood
vessels. Efficacy of thrombolysis with recombinant tissue plasminogen activator (rt-PA) has
been proven in a number of studies and currently is only approved therapy for acute
ischemic stroke treatment. In order to improve outcome, ischemic stroke patients need to
be treated in specialized units – stroke units. After early recognitions of stroke symptoms
and urgent diagnosis these units are a prerequisite for an urgent start of therapy with purpose
of early recanalization of blood vessels and reperfusion of brain parenchyma. This approach
in management of ischemic stroke patients makes it possible for circulation to be restored
in the ischemic region of the brain while neurons are still reversible damaged leading
to an improved outcome at the end.

Keywords

outcome; recanalization; recombinant tissue plasminogen activator; stroke units

Hrčak ID:

112538

URI

https://hrcak.srce.hr/112538

Publication date:

2.12.2013.

Article data in other languages: croatian

Visits: 8.959 *