Original scientific paper

https://doi.org/10.2478/acph-2014-0010

Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride

REHAB MOHAMMAD YUSIF ; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt
IRHAN IBRAHIM ABU HASHIM ; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt
MARWA SALAH EL-DAHAN ; Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

Abstract

Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation weight ratio was determined using viscosity measurements. Interactions between EE and SA inPECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Diltiazem hydrochloride (DTZ HCl) tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3) as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05) decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE-SAH and EE-SAL PECs.

Keywords

polyelectrolyte complex; diltiazem hydrochloride; Eudragit E 100; sodium alginate; viscosity; tablet matrix

Hrčak ID:

113593

URI

https://hrcak.srce.hr/113593

Publication date:

31.3.2014.

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