Original scientific paper
https://doi.org/10.3325/cmj.2013.54.550
Genetic and environmental variance of renal parenchymal thickness: a twin study
David Laszlo Tarnoki
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Adam Domonkos Tarnoki
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Levente Littvay
; Central European University, Budapest, Hungary
Pal Bata
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Viktor Berczi
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Zsolt Garami
; Houston Methodist DeBakey Heart & Vascular Center, The Houston Methodist Hospital, Houston, TX, USA
Kinga Karlinger
; Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary
Abstract
Aim To estimate heritability and environmental effects on
renal parenchymal thickness.
Methods In this twin study, renal parenchymal thickness
of 98 Hungarian healthy adult twin pairs (68 monozygotic,
30 dizygotic) without kidney disease was measured bilaterally
using renal ultrasound with Esaote MyLab 70X ultrasound
machine with low-frequency curved transducers
(1-8 MHz).
Results In both monozygotic and dizygotic group there
were more women (76.5%). Mean right and left renal parenchymal
thickness was 1.32 ± 0.33 cm and 1.62 ± 0.31
cm, respectively. Age- and sex-adjusted heritability of renal
parenchymal thickness was 0.0% (95% confidence interval,
0.0 to 50.2%), shared and unshared environmental
factor was 30.2% (4.1 to 55.9%) and 69.8% (45.8 to 89.5%),
respectively.
Conclusion This study shows a negligible role of heritability
and an important role of environmental effects in developing
renal parenchymal thickness, emphasizing the importance
of lifestyle for primary prevention.
Keywords
Hrčak ID:
117022
URI
Publication date:
15.12.2013.
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