Original scientific paper
https://doi.org/10.2478/10004-1254-65-2014-2398
Efficiency of hepatocyte pretreatment with coenzyme Q10 against statin toxicity
Mohammad Ali Eghbal
; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
Narges Abdoli
; Biotechnology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
Yadollah Azarmi
; Biotechnology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Statins are potent cholesterol-lowering drugs that can have serious adverse effects on the muscles and liver. The aim of our in vitro study was to establish the protective effect of coenzyme Q10 (CoQ10, in its optimal dose of 200 μmol L-1) against cytotoxicity induced by atorvastatin, simvastatin, and lovastatin in isolated rat hepatocytes by observing parameters such as cell death, reactive oxygen species formation, lipid peroxidation, mitochondrial membrane potential, and cellular reduced and oxidised glutathione content. Our findings have shown that pretreatment with CoQ10 was effective in reducing the toxic effects of statins in rat hepatocytes. This work demonstrates that the addition of CoQ10 to statin treatment regimens may protect hepatocytes (and also other types of cells) from statin-induced injuries and alleviate their side effects.
Keywords
atorvastatin; hepatotoxicity; lipid peroxidation; lovastatin; oxidative stress; reactive oxygen species; simvastatin; ubiquinone
Hrčak ID:
117135
URI
Publication date:
10.3.2014.
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