Original scientific paper
Total and LDL Cholesterol are Associated with Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients
Tomislav Bulum
; University of Zagreb, University Hospital Merkur, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, School of Medicine, Zagreb, Croatia
Branko Kolarić
; University of Rijeka, School of Medicine, Rijeka, Croatia
Ingrid Prkačin
; University of Zagreb, University Hospital Merkur, School of Medicine, Department of Internal medicine, Zagreb, Croatia
Lea Duvnjak
; University of Zagreb, University Hospital Merkur, »Vuk Vrhovac« Clinic for Diabetes, Endocrinology and Metabolic Diseases, School of Medicine, Zagreb, Croatia
Abstract
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We in- vestigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with es- timated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 mL/min per 1.73 m 2 ) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r= –0.21, –0.18, and –0.17, respectively, for all p <0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL cholesterol (2.9 vs 2.8 and 2.4 mmol/L). We have detected an association between eGFR and lipid abnormalities in type 1 diabetes in early stages. The study was conducted in patients with no therapeutic inter- vention. This may suggest that lipid abnormalities may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.
Keywords
type 1 diabetes; serum lipids; renal function; glomerular filtration rate
Hrčak ID:
118216
URI
Publication date:
30.9.2013.
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