Original scientific paper
Prevalence of Metabolic Syndrome among Patients with Major Depressive Disorder – Differences Between Newly Diagnosed First Episode and Recurrent Disease
Rudolf Ljubičić
; University of Zagreb, University Hospital Center »Sestre milosrdnice«, Department of Psychiatry, Zagreb, Croatia
Hrvoje Jakovac
; University of Rijeka, School of Medicine, Department of Physiology and Immunology, Rijeka, Croatia
Ivana Ljubičić-Bistrović
; University of Rijeka, University Hospital Centre Rijeka, Department of Psychiatry, Rijeka, Croatia
Tanja Frančeski
; University of Zagreb, University Hospital Center »Sestre milosrdnice«, Department of Psychiatry, Zagreb, Croatia
Ana Kovak Mufić
; University of Zagreb, University Hospital Center »Sestre milosrdnice«, Department of Psychiatry, Zagreb, Croatia
Dalibor Karlović
; University of Zagreb, University Hospital Center »Sestre milosrdnice«, Department of Psychiatry, Zagreb, Croatia
Abstract
The objective of the present study was to assess differences in prevalence of the metabolic syndrome among depressed patients in regard to the duration of the illness (first episode versus recurrent episodes). A total of 190 patients suffering from major depressive disorder were included in the study, diagnosed according to International classification of disor- ders, 10th revision 1 . The same criteria were used to divide participants into two groups: first episode major depressive disorder and major depressive disorder with recurrent episodes. The metabolic syndrome was defined according to the criteria of the American National Cholesterol Education Program-Treatment Panel III 2 . Results showed that metabolic syndrome is significantly more prevalent in patients with recurrent major depressive disorder (45.2%) compared to pa- tients with first episode of major depressive disorder (27.3%), mainly due to differences in plasma glucose, triglycerides and HDL-cholesterol levels. These findings indicate the importance of the duration of depression and the number of re- curring episodes as factors involved in etiopathogenesis of the associated metabolic syndrome.
Keywords
major depressive disorder; first episode; recurrent; metabolic syndrome; NCEP-ATP III; prevalence
Hrčak ID:
118340
URI
Publication date:
30.12.2013.
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