Original scientific paper
Polymorphisms of Interleukin-23 Receptor in Patients with Inflammatory Bowel Disease in a Croatian Tertiary Center
Silvio Mihaljević
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Internal Medicine Clinic, Division of Gastroenterology, Osijek, Croatia
Aleksandar Kibel
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Internal Medicine Clinic, Division of Gastroenterology, Osijek, Croatia
Mario Štefanić
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Clinic for Nuclear medicine and Radiation Protection, Osijek, Croatia
Ljubica Glavaš-Obrovac
; University »Josip Juraj Strossmayer«, School of Medicine, Department of Chemistry and Biochemistry, Osijek, Croatia
Boris Takač
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Clinic for Nuclear medicine and Radiation Protection, Osijek, Croatia
Željko Krznarić
; University of Zagreb, University Hospital Centre Zagreb, Internal Medicine Clinic, Division of Gastroenterology and Hepatology, Zagreb, Croatia
Marina Samardžija
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Department of Transfusion Medicine, Osijek, Croatia
Ljerka Pinotić
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Pediatric Clinic, Osijek, Croatia
Josip Milas
; Department of Public Health, Osijek, Croatia
Ivan Segec
; University »Josip Juraj Strossmayer«, University Hospital Centre Osijek, Internal Medicine Clinic, Division of Gastroenterology, Osijek, Croatia
Abstract
The Interleukin-23 signalling pathway is important for the differentiation of TH17 lymphocytes and is involved in the pathogenesis of Inflammatory bowel disease. Polymorphisms in the IL-23 receptor gene were previously found to be associated with Inflammatory bowel disease in various populations. The aim of this study was to determine whether the specific rs11209026 and rs7530511 single-nucleotide polymorphisms in the Interleukin-23 receptor gene are associated with Crohn’s disease and ulcerative colitis in a Croatian patient population. A total of 50 patients with Crohn’s disease and 93 patients with ulcerative colitis, as well as 99 healthy control subjects were included in the study. The results deter- mined a significantly higher occurrence of rs11209026 in control group compared to patients with inflammatory bowel disease, suggesting a protective effect of this polymorphism. The rs11209026 variant was strongly associated with Crohn’s disease, but it was absent in ulcerative colitis. However, there was no significant association between the rs7530511 poly- morphism with either ulcerative colitis or Crohn’s disease. Associations presented in this study give potentially impor- tant insight into the roles of specific Interleukin-23 receptor polymorphisms in Crohn’s disease pathogenesis in the Cro- atian population.
Keywords
Crohn’s disease; ulcerative colitis; Inflammatory bowel disease; interleukin-23 receptor; single nucleotide polymorphism; genotype; population; inflammation; cytokine; autoimmune
Hrčak ID:
118363
URI
Publication date:
30.12.2013.
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