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Journal of Electrochemical Science and Engineering, Vol. 4 No. 1, 2014.

Original scientific paper

https://doi.org/10.5599/jese.2014.0043

Determination of nevirapine in the presence of cucurbit(7)uril with a gold electrode

Ana Esteva ; Departamento de Química Analítica, Facultad de Química, Universidad de La Habana, La Habana 10400, Cuba
Elias Blanco ; Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain
Juan Pina ; Departamento de Química Analítica, Facultad de Química, Universidad de La Habana, La Habana 10400, Cuba
Abel Balbin ; Departamento de Química Analítica, Facultad de Química, Universidad de La Habana, La Habana 10400, Cuba
Carmen Quintana ; Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain
Pedro Hernandez ; Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid, Spain

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Abstract

The electrochemical oxidation of nevirapine, an anti-HIV drug, at a gold electrode was studied by voltammetric techniques. Nevirapine showed a signal that interfered with a working electrode wave. This interference was solved by the use of cucurbit(7)uril allowing nevirapine to be determined in tablets (80.4 % recovery, presence of stavudine and lamivudine) and urine (98.4 %).

Keywords

Antiretroviral; Voltammetry; Tablets; Urine

Hrčak ID:

119473

URI

https://hrcak.srce.hr/119473

Publication date:

25.1.2014.

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