Paediatria Croatica, Vol. 58 No. 1, 2014.
Original scientific paper
https://doi.org/10.13112/PC.2014.3
Urolithiasis – a potential complication of ceftriaxone therapy
Daniel Turudić
; Medicinski fakultet Sveučilišta u Zagrebu, 10000 Zagreb
Danica Batinić
; Medicinski fakultet Sveučilišta u Zagrebu, Klinički bolnički centar Zagreb, Zavod za nefrologiju, dijalizu i transplantaciju, 10000 Zagreb
Branko Miše
; Zavod za dječje zarazne bolesti, Sveučilište u Zagrebu, 10000 Zagreb
Ivan Habuš
; Odjel za fi zikalnu kemiju Instituta „Ruđer Bošković“, 10000 Zagreb
Marija Spajić
; Opća bolnica Karlovac, Karlovac
Goran Krnjak
; Medicinski fakultet Sveučilišta u Zagrebu, Klinički bolnički centar Zagreb, Zavod za nefrologiju, dijalizu i transplantaciju, 10000 Zagreb
Danko Milošević
; Medicinski fakultet Sveučilišta u Zagrebu, Klinički bolnički centar Zagreb, Zavod za nefrologiju, dijalizu i transplantaciju, 10000 Zagreb
Abstract
A cohort of 238 children diagnosed with cystopyelonephritis were retrospectively analyzed in 2011 to assess the possible ceftriaxone
risk of urinary stone formation. All children were treated with ceftriaxone in a standard dosage of 60 mg/kg/day for 10 days. Urinary
tract imaging revealed anomalies in 73, vesicoureteral refl ux in 66 and hydronephrosis in 7 children. No ceftriaxone stone formation
and no sign of abdominal colic or macro/microhematuria was found during one-month monitoring. Ceftriaxone administration is
quite safe in the usual dosage of 60 mg/kg/24 h for 10 days. Caution is only warranted in children requiring higher dosage of ≥100
mg/kg/24 h and prolonged administration. In such cases, we recommend ultrasound of urinary tract and gallbladder screening for
hypercalciuria and alkalization of urine.
Keywords
ceftriaxone; urinary calculi; urinary tract infections
Hrčak ID:
119997
URI
Publication date:
24.3.2014.
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