Professional paper

Laboratory diagnostics of ANCA-vasculitis

Ilza Salamunić ; Department for Medical Laboratory Diagnostics, Clinical Hospital Centre Split, Split, Croatia
Dušanka Martinović Kaliterna ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia

Abstract

The antineutrophil cytoplasmic antibody (ANCA) are associated with distinct forms of primary small vessel vasculitides, collectively reffered to as ANCA-associated vasculitis (AAV). ANCA were originally identified by IIF. Importantly, however, only ANCA directed to PR3 (PR3-ANCA) or MPO (MPO-ANCA) are relevant for the diagnosis AAV, there is international consensus that ANCA should be detected by a combination of IIF and antigen-specific assays, i.e. detection of PR3 and MPO-ANCA. Several novel technologies have become available for antigen-specific ANCA detection.

Keywords

ANCA; vasculitis; clinical laboratory diagnosis

Hrčak ID:

123337

URI

https://hrcak.srce.hr/123337

Publication date:

17.10.2013.

Article data in other languages: croatian

Visits: 4.249 *