Professional paper

Treatment of vasculitis

Srđan Novak ; Department for Rheumatology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Rijeka, Rijeka, Croatia

Abstract

Treatment of vasculitis depends on etiology and type of vasculitis. Gluccocorticoids are drug of choice in treatment of systemic vasculitis. While in vasculitis of large vessels treatment with gluccocorticoids is often sufficient, in ANCA associated vasculitis almost always intial combination of gluccocorticoids and immunosupresive drugs (cyclofosfamide in severe forms; azatioprin and metotrrexate in moderate disease) is needed. Maintance therapy of ANCA associated vasculitis is methotrexate or azatioprin. From biologic therapy, in gigantocellular vasculitis treatment with tocilizumb has a great expectation, while in ANCA associated vasculitis recently rituximab was approved by regulatory agencies, and it is nontinferior to cyclofosfamide in induction of remission and prefarable in relapsing disease.

Keywords

systemic vasculitis; treatment

Hrčak ID:

123340

URI

https://hrcak.srce.hr/123340

Publication date:

17.10.2013.

Article data in other languages: croatian

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