Professional paper

Pathology diagnosis of idiopathic inflammatory myopathies

Leo Pažanin ; Clinical Department for Pathology “Ljudevit Jurak”, Clinical Hospital Centre “Sestre milosrdnice”, Zagreb, Croatia

Abstract

The idiopathic inflammatory myopathies represent a group of immunologically mediated diseases characterized by inflammation of skeletal muscle potentially leading to irreversible damage. On the basis of clinical, histological and immunological features dermatomyositis, polymyositis and sporadic inclusion-body myositis are recognized as separate entities. A definitive diagnosis of idiopathic inflammatory myopathies requires detailed histological, histochemical, immunohistochemical and electron-microscopic analysis of adequate muscle biopsy sample. However, in spite of thorough morphological analysis distinction of these disorders is not always straightforward and a close clinicopathological correlation is often essential to reach a correct diagnosis. Detailed morphological features of idiopathic inflammatory myopathies and their relationship to pathogenesis is outlined.

Keywords

myositis; inflammatory myopathy; pathology diagnosis

Hrčak ID:

124038

URI

https://hrcak.srce.hr/124038

Publication date:

25.10.2012.

Article data in other languages: croatian

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