Professional paper

Pathophysiology of gout

Jasminka Milas-Ahić ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Višnja Prus ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia
Roberta Višević ; Clinical Department for Rheumatology, Allergology and Clinical Immunology, Clinic for Internal Medicine, Clinical Hospital Centre Osijek, Osijek, Croatia

Abstract

Hyperuricemia is rather often metabolic disorder in general population. It is multifactorial disorder influenced by purine rich diet, alcohol consumption, diuretics use and renal deterioration. In the presence of local urate superasturation and lower solubility, monosodium crystals are deposited in joints, kidneys and soft tissue leading to clinical manifestations, such as gout, tophaceus deposits, nephrolithiasis and uric nephropathy. Major advances in understanding the pathogenesis of hyperuricemia and gout have been made recently, including genetic studies of urate transporters in kidneys as well as innate immune inflammatory responses and cytokine production which will be discussed thoroughly in this paper.

Keywords

patophysiology; gout; hyperuricemia

Hrčak ID:

124048

URI

https://hrcak.srce.hr/124048

Publication date:

25.10.2012.

Article data in other languages: croatian

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