Professional paper

Treatment of systemic lupus erythematosus

Dijana Perković ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia
Dušanka Martinović Kaliterna ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia
Daniela Marasović Krstulović ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia

Abstract

Treatment of systemic lupus erythematosus is very difficult because of heterogeneous clinical manifestations. Standard therapy includes non-steroidal anti-inflammatory drugs, glucocorticoids, antimalarials and cytotoxic agents. A numerous biological agents have been investigated for treatment of the systemic lupus erythematosus. They are directed to B and T cell depletion, blockade of co-stimulatory molecules, inhibition of cytokines and complement modulation. Sirolimus, tacrolimus, autologous hematopoietic stem cell transplantation and allogenic mesenchymal stem cells transplantation have been also investigated for treatment of systemic lupus erythematosus.

Keywords

systemic lupus erythematosus; treatment; glucocorticoids; cytotoxic agents; biological agents

Hrčak ID:

124382

URI

https://hrcak.srce.hr/124382

Publication date:

1.4.2012.

Article data in other languages: croatian

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