Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?

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Signa vitae : journal for intesive care and emergency medicine, Vol. 2 No. 1, 2007.

Review article

Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?

Dejan Kupnik ; The Center for Emergency Medicine Maribor, Ulica talcev 9, 2000 Maribor, Slovenia
Štefek Grmec ; The Center for Emergency Medicine Maribor, Ulica talcev 9, 2000 Maribor, Slovenia

Full text: english pdf 53 Kb

page 11-14

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APA 6th Edition

Kupnik, D. & Grmec, Š. (2007). Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?. Signa vitae, 2 (1), 11-14. Retrieved from https://hrcak.srce.hr/11963

MLA 8th Edition

Kupnik, Dejan and Štefek Grmec. "Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?." Signa vitae, vol. 2, no. 1, 2007, pp. 11-14. https://hrcak.srce.hr/11963. Accessed 24 Nov. 2024.

Chicago 17th Edition

Kupnik, Dejan and Štefek Grmec. "Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?." Signa vitae 2, no. 1 (2007): 11-14. https://hrcak.srce.hr/11963

Harvard

Kupnik, D., and Grmec, Š. (2007). 'Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?', Signa vitae, 2(1), pp. 11-14. Available at: https://hrcak.srce.hr/11963 (Accessed 24 November 2024)

Vancouver

Kupnik D, Grmec Š. Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?. Signa vitae [Internet]. 2007 [cited 2024 November 24];2(1):11-14. Available from: https://hrcak.srce.hr/11963

IEEE

D. Kupnik and Š. Grmec, "Erythropoietin in post-resuscitation neurological recovery: is there light at the end of the tunnel?", Signa vitae, vol.2, no. 1, pp. 11-14, 2007. [Online]. Available: https://hrcak.srce.hr/11963. [Accessed: 24 November 2024]

Abstract

Studies show that erythropoietin, besides its critical role in hematopoiesis, provides neuroprotection in hypoxic-ischemic cerebral injury. Antiapoptotic, anti-inflammatory, angiogenetic, and neurotrophic properties of erythropoietin could increase indications, currently restricted to anemia in chronic renal failure and cancer, to hypoxic-ischemic cerebral insult.
In the adult and neonatal animal model of hypoxic-ischemic cerebral injury, erythropoietin significantly reduces infarct size with attenuation of brain damage, and preservation of cortical integrity. The first human study on the impact of erythropoietin in stroke victims showed that erythropoietin is safe and well tolerated at high doses, and associated with improved neurological outcome. Even with intravenous application, concentrations of erythropoietin in cerebrospinal fluid of these patients were many-fold higher than in non-treated patients.
In successfully resuscitated cardiac arrest victims overall neurological recovery remains poor despite improved cardiopulmonary resuscitation strategies. Post-resuscitation care needs further advances in order to improve final outcome. Through promotion of neuroangiogenesis, inhibition of hypoxia-induced apoptosis in neurons, and thus support of the survival of neurons in the ischemic brain, erythropoietin could be used to improve functional recovery of these patients. Nevertheless, optimal molecular forms of EPO, therapeutic doses, and treatment time window have to be determined in order to lower the incidence of adverse effects and still preserve neuroprotective properties.

Keywords

cardiopulmonary resuscitation; erythropoietin; post-resuscitation period; hypoxia

Hrčak ID:

11963

URI

https://hrcak.srce.hr/11963

Publication date:

1.4.2007.

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