Reumatizam, Vol. 55 No. 2, 2008.
Conference paper
Strontium ranelate’s (Osseor®) dual mode of action: increasing bone mass and decreasing bone resorption
Dušanka Martinović Kaliterna
; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia
Abstract
Strontium ranelate has unique dual mode of action on bone remodeling through increased bone formation and decreased bone resorption. As a consequence, there is increased bone mass and bone strength, leading to reduced number of vertebral and nonvertebral fractures. Although strontium bone distribution is heterogeneous, higher concentrations of strontium are found in younger bones. Long term treatment with strontium ranelate does not lead to any change in bone mineral distribution, mineral composition or crystal stability, nor is strontium accumulated in bone.
Keywords
strontium ranelate; bone mass; bone resorption; minerals
Hrčak ID:
125251
URI
Publication date:
17.10.2008.
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