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Professional paper

Anticonvulsant induced metabolic disorder - case report

Dušanka Martinović Kaliterna ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia
Zrinka Jurišić ; Department for Cardiology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia


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Abstract

Osteomalacia, metabolic bone disease in the adults, is disorder in which mineralization of the organic matrix of the skeleton is defective. This disorder is caused by a number of different conditions associated with alterations of vitamin D metabolism. Anticonvulsant therapy can also cause the development of osteomalacia due to alteration of vitamin D metabolism inducing hepatic mycrosomal enzymes, inhibiting 25-hydroxilation of vitamin D. They also inhibit intestinal calcium transport and bone mineral mobilization, independent of effects on vitamin D metabolism. This paper presents a patient who was unable to walk due to anticonvulsants induced osteomalacia. Anticonvulsant use has been implicated as a cause of bone disease for more than 30 years but there is no official recommendation for calcium and vitamin D therapy in anticonvulsant treated individuals.

Keywords

anticonvulsants; side-effect; osteomalacia

Hrčak ID:

125315

URI

https://hrcak.srce.hr/125315

Publication date:

1.7.2008.

Article data in other languages: croatian

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