Professional paper

Anticonvulsant induced metabolic disorder - case report

Dušanka Martinović Kaliterna ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia
Zrinka Jurišić ; Department for Cardiology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia

Abstract

Osteomalacia, metabolic bone disease in the adults, is disorder in which mineralization of the organic matrix of the skeleton is defective. This disorder is caused by a number of different conditions associated with alterations of vitamin D metabolism. Anticonvulsant therapy can also cause the development of osteomalacia due to alteration of vitamin D metabolism inducing hepatic mycrosomal enzymes, inhibiting 25-hydroxilation of vitamin D. They also inhibit intestinal calcium transport and bone mineral mobilization, independent of effects on vitamin D metabolism. This paper presents a patient who was unable to walk due to anticonvulsants induced osteomalacia. Anticonvulsant use has been implicated as a cause of bone disease for more than 30 years but there is no official recommendation for calcium and vitamin D therapy in anticonvulsant treated individuals.

Keywords

anticonvulsants; side-effect; osteomalacia

Hrčak ID:

125315

URI

https://hrcak.srce.hr/125315

Publication date:

1.7.2008.

Article data in other languages: croatian

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