Professional paper

Proposal for anti-TNFα therapy in adult patients with rheumatoid arthritis

Božidar Ćurković ; Croatian Society for Rheumatology of the CMA, Zagreb, Croatia
Đurđica Babić-Naglić ; Croatian Society for Rheumatology of the CMA, Zagreb, Croatia
Jadranka Morović-Vergles ; Croatian Society for Rheumatology of the CMA, Zagreb, Croatia
Branimir Anić ; Croatian Society for Rheumatology of the CMA, Zagreb, Croatia
Simeon Grazio ; Croatian Society for Rheumatology of the CMA, Zagreb, Croatia

Abstract

Rheumatoid arthritis is a chronic, inflammatory disease with the prevalence about 1%. Rheumatoid arthritis is characterized with synovitis, erosive changes of the joints, pain and functional deficit. Etiology of the disease is unknown. In the pathogenesis of rheumatoid arthritis the key role have proinflammatory citokines, particularly, tumour necrosis factor (TNFα). TNFα blockers have documented, fast and continuous efficacy with generaly well accepted safety profile. Nowadays, TNFα antagonists are established drugs in early and late phase of rheumatoid arthritis. Prescription of TNFα antagonists is controlled, according local restrictions, regarding high costs of the therapy. On behalf of the Croatian Society for Rheumatology we propose recommendations for the TNFα antagonist therapy in rheumatoid arthritis.

Keywords

rheumatoid arthritis; TNF inhibitors; recommendations

Hrčak ID:

125391

URI

https://hrcak.srce.hr/125391

Publication date:

1.7.2007.

Article data in other languages: croatian

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