Reumatizam, Vol. 53 No. 1, 2006.
Review article
HLA-B27 gene: polymorphism, evolution, distribution, and association with spondyloartopathies
Zorana Grubić
; Department for Tissue Typing, Clinic for Urology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Abstract
The association between HLA-B27 and ankylosing spondylitis is well established more than thirty years. In spite of numerous studies in this field, a lot of unknown is still present. In this review, polymorphism, evolution, distribution and current pathogenetic hypotheses are presented.
Keywords
HLA-B27; polymorphism; evolution; ankylosing spondylitis; spondyloarthropathies; population study
Hrčak ID:
125881
URI
Publication date:
1.7.2006.
Visits: 2.732 *