Conference paper

Pharmacotherapy of osteoarthritis

Božidar Ćurković ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia

Abstract

Published guidelines for medical treatment of osteoarthritis nonpharmacological treatment considered as the cornerstone of OA management and all the pharmacological agents should be added to nonpharmacological measures. Drugs in the treatment of osteoarthritis could be shared into fast acting symptomatic, slow acting symptomatic and disease modifying (structure) drugs and shorthly are described in this paper. According ACR and EULAR guidelines paracetamol had to be the first pharmacological choice based on efficacy, tolerability and cost. Data from literature do not support efficacy of paracetamol in treatment of moderate to severe form of osteoarthritis. Randomized controlled trials and metaanalyses show no statistically significant difference in adverse events between paracetamol in maximal daily dose and nonsteroidal anti-inflammatory drugs. Nonsteroidal anti-inflammatory drugs would be first choice for treatment of moderate to severe form of osteoarthritis in lowest effective dose and shortest duration of therapy.

Keywords

osteoarthritis; pharmacologic treatment

Hrčak ID:

125918

URI

https://hrcak.srce.hr/125918

Publication date:

14.10.2005.

Article data in other languages: croatian

Visits: 1.241 *