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Reumatizam, Vol. 52 No. 1, 2005.

Original scientific paper

DRB1 gens distribution in Croatian arthritis patients

Nadica Laktašić-Žerjavić ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Dragica Soldo-Jureša ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital “Dubrava”, Zagreb, Croatia
Đurđica Babić-Naglić ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Božidar Ćurković ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Kristina Potočki ; Clinical Department for Diagnostic and Interventional Radiology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Renata Žunec ; Department for Tissue Typing, Clinic for Urology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Goran Ivanišević ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia

Full text: croatian pdf 438 Kb

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Abstract

Genetic association between particular HLA-DRB1 genes and severity of rheumatoid arthritis (RA) has been documented in various clinical investigations. Susceptible alleles are *0401, *0404, *0405, *0408, *0101, *1001, *1402. According to the Shared epitope hypothesis presence of these alleles were considered as poor prognostic sign. The aim was to investigate HLA-DRB1 distribution in Croatian arthritis patients. Group of 90 patients with non-specific joint arthritis, non-erosive RA and erosive RA were typed for DRB1 alleles by PCR-SSP method. Susceptible alleles were identified in 58 (64.44 %) patients. The most frequent genes were DRB1 *0101 (43.33 %), *0401 (17.77 %), *0404 (10 %). 9 out of 58 DRB1* positive patients had 2 susceptible alleles, and the rest (49 patients) had only one susceptible allele. The patients with non-specific joint arthritis and non-erosive RA will bee closely followed for more destructive disease course in DRB1* positive patients.

Keywords

rheumatoid arthritis; shared epitope; HLA-DRB1 alleles

Hrčak ID:

125958

URI

https://hrcak.srce.hr/125958

Publication date:

1.7.2005.

Article data in other languages: croatian

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