Reumatizam, Vol. 51 No. 1, 2004.
Original scientific paper
The distribution of HLA alleles class I and class II among patientes with psoriatic arthritis in Croatia
Zorana Grubić
; Department for Tissue Typing, Clinic for Urology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Porin Perić
; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Esma Čečuk-Jeličić
; Department for Tissue Typing, Clinic for Urology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Renata Žunec
; Department for Tissue Typing, Clinic for Urology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Božidar Ćurković
; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Vesna Kerhin-Brkljačić
; Department for Tissue Typing, Clinic for Urology, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Abstract
The aim of the present study was to analyze the distribution of HLA-A, -B, -Cw, and -DRB1 alleles among patients with psoriatic arthritis (PsA) in Croatia. DNA was isolated from peripheral blood of 58 PsA patients (28 male and 30 female) and tested by PCR-SSP (Polymerase Chain Reaction - Sequence Specific Primers) method for polymorphism of the above mentioned HLA loci. The strongest association between psoriatic arthritis and HLA in the Croatian population was observed for alleles at HLA-B locus (B*39 and B*57), while the association of B*27 and B*13 alleles with PsA reached significance only before correction of p value with the number of tested alleles. Higher frequency of Cw*02 and DRB1*16 alleles is a result of linkage disequilibrium between these alleles and HLA-B alleles associated with PsA in Croatia. We also observed lower frequency of B*0702, B*18 and B*38 alleles in our group of patients.
Keywords
HLA; psoriatic arthritis; population study; Croatia
Hrčak ID:
126024
URI
Publication date:
1.8.2004.
Visits: 6.018 *