Medicus, Vol. 23 No. 2. Liječenje boli, 2014.
Review article
From Genomics to Metabolomics of Analgesics in Children
Jasminka Jakobović
Abstract
Personalised medicine or individualised medicamentous treatment based on patient’s genetics was expected to develop from the human genome project. Pharmacogenomics is a science investigating interactions between human genome and clinical drug response. However, the complexity of drug-patient interactions is not only patient genome dependent, but it also depends on many other factors like environmental, drug to drug interactions, and transporter and receptor polymorphism. The situation in children is even more complex given ontogenomics and the development of functional enzymes related to the chronological age of the child, which in turn creates variability in pharmacokinetics and pharmacodynamics.
Keywords
personalized medicine; pharmacogenomics; metabolomics; pain; children; analgesics; ontogenomics
Hrčak ID:
127305
URI
Publication date:
24.9.2014.
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