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Review article

From Genomics to Metabolomics of Analgesics in Children

Jasminka Jakobović


Full text: croatian pdf 1.526 Kb

page 117-126

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Abstract

Personalised medicine or individualised medicamentous treatment based on patient’s genetics was expected to develop from the human genome project. Pharmacogenomics is a science investigating interactions between human genome and clinical drug response. However, the complexity of drug-patient interactions is not only patient genome dependent, but it also depends on many other factors like environmental, drug to drug interactions, and transporter and receptor polymorphism. The situation in children is even more complex given ontogenomics and the development of functional enzymes related to the chronological age of the child, which in turn creates variability in pharmacokinetics and pharmacodynamics.

Keywords

personalized medicine; pharmacogenomics; metabolomics; pain; children; analgesics; ontogenomics

Hrčak ID:

127305

URI

https://hrcak.srce.hr/127305

Publication date:

24.9.2014.

Article data in other languages: croatian

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