Original scientific paper

The Synthesis and Hybridization Studies of Oligodeoxyribonucleotides Containing the 2'-Deoxyguanosine Modification, 8-Aza-3-deaza-2'-deoxyguanosine

Suzana Jakša ; National Institute of Chemistry, Hajdrihova 19, SI-1115 Ljubljana, Slovenia
Bogdan Kralj ; Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia
Jože Kobe ; National Institute of Chemistry, Hajdrihova 19, SI-1115 Ljubljana, Slovenia

Abstract

Chemical and physical properties of the modified nucleoside 8-aza-3-deaza-2’-deoxyguanosine (1) are described. From the amino protected nucleoside 1a, phosphoramidite 3 was prepared, and oligo-deoxyribonucleotides were synthesized. Duplexes containing compound 1 are slightly less stable than the natural duplex.

Keywords

synthesis; oligodeoxyribonucleotides; 8-aza-3-deaza-2’-deoxyguanosine; melting studies

Hrčak ID:

127494

URI

https://hrcak.srce.hr/127494

Publication date:

4.2.2002.

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