Original scientific paper

Alzheimer and Lewy body pathology or Creutzfeldt-Jakob disease

Ana Krvavica ; eneral Hospital Zadar, Department of Pathology and Forensic Medicine, Zadar, Croatia
Miro Morovic ; University in Rijeka, General Hospital Zadar, Department of Infective Diseases, Zadar, Croatia
Anamarija Mrđen ; General Hospital Zadar, Department of Neurology, Zadar, Croatia
Mišlov Damir ; General Hospital Zadar, Department of Neurology, Zadar, Croatia
Klaudia Duka-Glavor ; General Hospital Zadar, Department of Neurology, Zadar,
Krešimir Ivanac ; General Hospital Zadar, Department of Neurology, Zadar, Croatia
Ellen Gelpi ; Medical University of Vienna, Austrian Reference Centre for Human Prion Diseases, Institute of Neurology, Vienna, Austria

Abstract

he objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropathological work-up. Neuropathological examination excluded Creutzfeldt-Jakob disease. By contrast other neurodegenerative changes combining Alzheimer-type pathology and Lewy body pathology were detected as the most likely substrate of neurological symptoms. Dementia with Lewy bodies should be included in the differential diagnosis in individuals presenting with rapidly progressive dementia.

Keywords

dementia; Lewy body; Alzheimer disease; Parkinson disease; Creutzfeldt-Jakob disease

Hrčak ID:

127611

URI

https://hrcak.srce.hr/127611

Publication date:

30.6.2014.

Visits: 922 *