Acta Pharmaceutica, Vol. 65 No. 1, 2015.
Short communication, Note
https://doi.org/10.1515/acph-2015-0005
Development and optimization of the activated charcoal suspension composition based on a mixture design approach
JOANNA RONOWICZ
; Department of Inorganic and Analytical Chemistry
BOGUMIŁA KUPCEWICZ
; Department of Inorganic and Analytical Chemistry
ŁUKASZ PAŁKOWSKI
; Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, 85-089 Bydgoszcz, Poland
JERZY KRYSIŃSKI
; Department of Pharmaceutical Technology, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, 85-089 Bydgoszcz, Poland
Abstract
In this study, a new drug product containing activated charcoal was designed and developed. The excipient levels in the pharmaceutical formulation were optimized using a mixture design approach. The adsorption power of the activated charcoal suspension was selected as the critical quality attribute influencing the efficacy of medical treatment. Significant prognostic models (p < 0.05) were obtained to describe in detail the interrelations between excipient levels and the adsorption power of the formulation. Liquid flavour had a critical impact on the adsorption power of the suspension. Formulations containing the largest amount of liquid flavour showed the lowest adsorption power. Sorbitol was not adsorbed onto the activated charcoal so strongly as liquid flavour. A slight increase in the content of carboxymethylcellulose sodium led to a marked decrease in adsorption power. The obtained mathematical models and response surface allowed selection of the optimal composition of excipients in a final drug product.
Keywords
activated charcoal; adsorption power; phenazone; experimental design; Quality by Design concept
Hrčak ID:
128392
URI
Publication date:
31.3.2015.
Visits: 2.031 *