Acta Pharmaceutica, Vol. 65 No. 2, 2015.
Original scientific paper
https://doi.org/10.1515/acph-2015-0015
Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes
WITOLD LASEK
; Department of Immunology, Centre of Biostructure Research, Medical University of Warsaw, Warsaw, Poland
MICHAŁ JANYST
; Department of Immunology, Centre of Biostructure Research, Medical University of Warsaw, Warsaw, Poland
RAFAŁ WOLNY
; Department of Immunology, Centre of Biostructure Research, Medical University of Warsaw, Warsaw, Poland
ŁUKASZ ZAPAŁA
; Department of Immunology, Centre of Biostructure Research, Medical University of Warsaw, Warsaw, Poland
KATARZYNA BOCIAN
; Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland
NADZIEJA DRELA
; Department of Immunology, Faculty of Biology, University of Warsaw, Warsaw, Poland
Abstract
Inosine pranobex (inosine dimepranol acedoben, isoprinosine) (Inos) is an immunomodulatory and antiviral drug used in some viral infections, especially in patients with weakened immunity. In the present study, effects of Inos on the production of cytokines attributable to Th1 (IL-2, IFN-γ, and TNF-α) or Th2 cells (IL-4, IL-5, and IL-10) were tested in human peripheral blood lymphocyte cultures stimulated with phytohemagglutinin (PHA). Inos enhanced TNF-α secretion significantly (in short-term – 24-hour, and prolonged term – 72-hour cultures) and IFN-γ (in 72-hour cultures). Surprisingly, production of IL-10 by PHA-stimulated lymphocytes was suppressed by Inos in a dose-dependent manner in both 24-hour and 72-hour cultures. These results shed some light on immunomodulatory properties of Inos and suggest applicability of this agent in patients with a depressed function of the immune system.
Keywords
inosine pranobex; immunomodulation; cytokines; IL-10
Hrčak ID:
128994
URI
Publication date:
30.6.2015.
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