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Acta Pharmaceutica, Vol. 65 No. 2, 2015.

Original scientific paper

https://doi.org/10.1515/acph-2015-0020

Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics

TING-TING LI ; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China; Pharmacy Department of People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, China
JIAN-ZHONG XIE ; Pharmacy Department of People's Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, China
LING WANG ; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education , West China School of Pharmacy, Sichuan University, Chengdu, China
YANG-YANG GAO ; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education , West China School of Pharmacy, Sichuan University, Chengdu, China
XUE-HUA JIANG ; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education , West China School of Pharmacy, Sichuan University, Chengdu, China

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Abstract

Fructose-1,6-diphosphate (FDP), a glycolytic metabolite, has been reported to protect susceptible organs during hypoxia or ischemia. However, there is paucity of human data on its pharmacokinetics after being exogenously administered. In the current study, the preliminary pharmacokinetics of FDP given orally to humans was investigated, and no typical peak was observed in the serum drug-time curve. Then, the pharmacokinetic studies were performed following multiple doses of of FDP in rats, and the Caco-2 monolayer model was used to study the absorption of FDP in vitro. The results suggested that plasma FDP concentration was significantly increased after oral multiple doses of 180 mg kg-1 but not 90 mg kg-1 of FDP, and FDP was partly depleted during the absorption, which was supposed to be consumed by the intestinal epithelium cells. Thus, we conclude that a high dose of FDP should be orally administered in order to get an effective plasma level.

Keywords

fructose-1,6-diphosphate; ischemia; hypoxia; pharmacokinetics

Hrčak ID:

128999

URI

https://hrcak.srce.hr/128999

Publication date:

30.6.2015.

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