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Physical and Rehabilitation Medicine, Vol. 21 No. 1-2, 2007.

Review article

Early diagnosis of rheumatoid arthritis

Đurđica BABIĆ-NAGLIĆ ; Clinic for reumatic diseases and rehabilitation Clinical Hospital Center Zagreb, Kišpatićeva 12, Zagreb
Iva ŽAGAR ; Clinic for reumatic diseases and rehabilitation Clinical Hospital Center Zagreb, Kišpatićeva 12, Zagreb

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Abstract

Rheumatoid arthritis (RA) is chronic joint disease which if untreated leads to permanent structural damage and disability. Early diagnosis and therapy are the main requests for good clinical practice. Early diagnosis tools include specific clinical assesment, serological, immunogenetic and radiological evaluation. Disease activity score is cornerstone in clinical assesment, rheumatoid factor and anti-cyclic
citrullinated peptide antibodies (anti-CCP) are very specific serological parameters. The shared epitope containing HLA-DRB1 alleles represent the most significant genetic risk for RA. Magnetic resonance and ultrasound imaging are very sensitive methods for erosion detection in early phase of the disease.

Keywords

rheumatoid arthritis; early diagnosis; anti-CCP; HLA-DRB1

Hrčak ID:

129198

URI

https://hrcak.srce.hr/129198

Publication date:

28.7.2006.

Article data in other languages: croatian

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