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Review article

Intramolecular Autoregulatory Sequences in Proteins

Bostjan Kobe orcid id orcid.org/0000-0001-9413-9166 ; Department of Biochemistry and Molecular Biology, and Institute for Molecular Bioscience, University of Queenslandy Brisbane 4072, Australia


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Abstract

The worldwide structural genomics initiative promises, within the next decade, to provide us with the three-dimensional structures of most representative proteins. However, the initiative does not in the initial stages specifically address the structural basis of protein-protein interactions and protein regulation, both of which are crucial for understanding the cellular function of proteins. This report reviews the studies of the structural basis of protein-protein interactions and regulation in several biologically important cellular processes carried out in our laboratory. The focus will be on the recognition of nuclear localization sequences (NLSs) by the nuclear import factor importin-α, and its regulation. Regulatory interactions in retroviral envelope proteins and the enzyme phenylalanine hydroxylase (PAH) will be discussed also. Ali three biological systems share a regulatory mechanism termed active sitedirected or intrasteric regulation.

Keywords

active site-directed/intrasteric regulation, importin-α/ karyopherin-α, membrane fusion, nuclear localization signal, phenylalanine hydroxylase, protein-protein interactions, protein structure, viral envelope proteins, X-ray crystallography

Hrčak ID:

129323

URI

https://hrcak.srce.hr/129323

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