Original scientific paper

Influence of ofloxacin on the disposition kinetics of meloxicam following single intravenous administration in goats.

Rajkumar S. Yadav ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, UP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan, Vishwavidyalaya Evam Go Anusandhan Sansthan Mathura, India
Satish K. Garg ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, UP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan, Vishwavidyalaya Evam Go Anusandhan Sansthan Mathura, India
Anu Rahal ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, UP Pt. Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan, Vishwavidyalaya Evam Go Anusandhan Sansthan Mathura, India

Abstract

The objective of the present study was to investigate the effect of ofloxacin (10 mg/kg) on the pharmacokinetics of meloxicam (0.5 mg/kg) in goats, when administered concurrently by intravenous route. Meloxicam concentration in plasma was measured using HPLC assay. The pharmacokinetics of meloxicam were best described by the two-compartment open model. Following concurrent administration of meloxicam and ofloxacin, the mean plasma level of meloxicam was only found to be significantly higher (P<0.05) at 15 min compared to its alone administration. Statistical analysis of data revealed that there were no statistically significant differences in PK parameters between the two treatments, except K21. Therefore, the results of the present study suggest that concurrent administration of ofl oxacin and meloxicam in goats does not require any adjustment in dosage regimens. Based on PK determinants, meloxicam may be administered by i.v. route at 0.86 and 0.65 mg/kg, as loading and maintenance doses respectively, and is to be repeated at 8 h intervals.

Keywords

meloxicam; ofloxacin; HPLC; pharmacokinetic; interaction; goats

Hrčak ID:

130408

URI

https://hrcak.srce.hr/130408

Publication date:

5.12.2014.

Article data in other languages: croatian

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