Original scientific paper

https://doi.org/10.5562/cca2360

Palladium Complexes with 3-Substituted Derivatives of 5-Methyl-5-(4-pyridyl)hydantoins. Synthesis, Study and in vitro Cytotoxicity

Adriana Bakalova ; Department of Chemistry, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria
Rossen Buyukliev ; Department of Chemistry, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria
Georgi Momekov ; Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University - Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria

Abstract

Six palladium(II) and palladium(IV) complexes with 3-ethyl-5-methyl-5-(4-pyridyl)hydantoin, 3-propyl-5-methyl-5-(4-pyridyl)hydantoin and 3-benzyl-5-methyl-5-(4-pyridyl)hydantoin were synthe-sized. The complexes were identified and characterized by elemental analysis, IR, 1H, 13C NMR spec-tra etc. On the data obtained the molecular formulae of the new palladium complexes were proposed. The
cytotoxicity of the complexes was evaluated in vitro using a panel of human tumour cell lines. The re-sults demonstrate that the Pd(II) complex with 3-benzyl-5-methyl-5-(4-pyridyl)hydantoin exerts cyto-toxicity as compared to the other studied Pd(II) complexes in all tested cell lines.

Keywords

Pd(II) and Pd(IV) complexes; 3,5-disubstituted hydantoins; cytotoxicity

Hrčak ID:

130426

URI

https://hrcak.srce.hr/130426

Publication date:

18.11.2014.

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